The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."
American Dad is another classic created by Seth McFarlane. It has remained the same hilarious show for 17 seasons now and is just as funny now as when it first started. While it's not as good as McFarlane's other classic animated show Family Guy, it's still one of the better animated shows aimed at adults that I've ever seen. It's amazing to me that it has been able to stay as funny as it has over that many seasons and doesn't look like it's slowing down anytime soon. It went on hiatus for a while and then TBS made the incredibly smart decision to bring it back because it's now one of their best shows.