Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Cassie Nightingale, Middleton's favorite enchantress, and her young-teenage daughter Grace, who shares that same special intuition as her mom, welcome Dr. Sam Radford and his son to town. When the New York transplants move in next to the Grey House, they are immediately spellbound by the mother-daughter duo next door, but Sam and Cassie quickly find they may not see eye to eye. With her signature charm, Cassie attempts to bring everyone together, ensuring all of Middleton is in for new changes, big surprises and, of course, a little bit of magic! "Good Witch" is based on Bell's beloved character Cassie, the raven-haired enchantress who kept audiences spellbound for seven installments of Hallmark Channel's longest-running and highest-rated original movie franchise of all time.

The story of Hugh Knight, a rising heart surgeon who is gifted, charming and infallible. He is a hedonist who, due to his sheer talent, believes he can live outside the rules. His "work hard, play harder" philosophy is about to come back and bite him.